For Official Use DAF / COMP / WP 2 / WD ( 2009 ) 31
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daf-31 Encodes the Catalytic Subunit of N Alpha-Acetyltransferase that Regulates Caenorhabditis elegans Development, Metabolism and Adult Lifespan
The Caenorhabditis elegans dauer larva is a facultative state of diapause. Mutations affecting dauer signal transduction and morphogenesis have been reported. Of these, most that result in constitutive formation of dauer larvae are temperature-sensitive (ts). The daf-31 mutant was isolated in genetic screens looking for novel and underrepresented classes of mutants that form dauer and dauer-lik...
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Wilson's disease (WD) is an inherited disorder of copper metabolism. Despite being treatable, patients with WD suffer severe disabilities due to delay in initiation and difficulty in monitoring treatment. We propose a two tier, Global Assessment Scale for Wilson's Disease (GAS for WD) that grades the multisystemic manifestations of the disease. Tier 1 scores the global disability in four domain...
متن کاملMaize response to water, salinity and nitrogen levels: yield-water relation, water-use efficiency and water uptake reduction function
Water, salinity and nitrogen are the major factors affecting maize production in arid and semi-arid areas. The objectives of this study were to investigate the effects of different water, salinity and nitrogen levels on yield-water relationships, water use, water productivity (WP), water use efficiency (WUE) and water uptake reduction function by maize hybrid SC-704 in a semi-arid area and ...
متن کاملStimulation of movement in a quiescent, hibernation-like form of Caenorhabditis elegans by dopamine signaling.
One of the characteristics of animals in hibernation is reduced behavioral activity. The Caenorhabditis elegans dauer state is a hibernation-like state of diapause that displays a dramatic reduction in spontaneous locomotion. A similar dauer-like quiescent state is produced in adults by relatively strong mutations in the insulin/IGF-1 receptor homolog daf-2. In this study, we show that mutation...
متن کاملIntraflagellar transport/Hedgehog-related signaling components couple sensory cilium morphology and serotonin biosynthesis in Caenorhabditis elegans.
Intraflagellar transport in cilia has been proposed as a crucial mediator of Hedgehog signal transduction during embryonic pattern formation in both vertebrates and invertebrates. Here, we show that the Hh receptor Patched-related factor DAF-6 and intraflagellar transport modulate serotonin production in Caenorhabditis elegans animals, by remodeling the architecture of dendritic cilia of a pair...
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تاریخ انتشار 2009